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What is NMN (Nicotinamide Mononucleotide)

David Sinclair, NMN, NR ANTI-AGING

A Journey to Better Health

Have you ever heard of Nicotinamide Mononucleotide (NMN)? If not, you’re about to embark on a journey into the fascinating world of this naturally occurring molecule that exists in every living cell. At the molecular level, NMN belongs to a class of molecules called nucleotides, the essential building blocks of RNA and DNA. Structurally, NMN consists of three key chemical groups: a phosphate group, a ribose sugar, and a nicotinamide base. What makes NMN particularly intriguing is its direct conversion into nicotinamide adenine dinucleotide (NAD+), often referred to as an NAD+ booster.

Why Boost NAD+ with NMN Matters

NAD+ is more than just a mouthful of scientific jargon; it’s a vital coenzyme, essentially a molecular helper, that enzymes rely on to carry out their functions. Enzymes are specialized proteins that make biological reactions occur much faster. Without enzymes, some crucial biological processes would take an unfathomable 2.3 billion years to complete. In essence, life as we know it depends on enzymes.

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As we age or grapple with chronic diseases like obesity, cardiovascular issues, neurodegenerative conditions, and sarcopenia (age-related muscle loss), our NAD+ levels tend to dwindle. This decline in NAD+ levels can have adverse effects on our health. However, NMN steps in as a potential game-changer, capable of mitigating the effects of aging and potentially preventing or even reversing chronic diseases by restoring NAD+ levels. The evidence supporting the anti-aging and pro-longevity effects of NAD+ boosters like NMN is steadily growing, backed by scientific research conducted on both animal models and humans.

NAD+ Activates Sirtuins: Guardians of the Cell

NAD+ plays a pivotal role in fueling a class of enzymes known as sirtuins. These remarkable enzymes have earned the moniker “guardians of the cell” because of their vital roles in repairing DNA and supporting mitochondrial health. Mitochondria, often dubbed the cell’s powerhouses, generate cellular energy known as ATP. Unhealthy mitochondria produce less ATP, leading to cell death. Moreover, excessive DNA damage can also spell doom for cells. Sirtuins come to the rescue by promoting cell survival through DNA repair and by maintaining pristine mitochondria.

According to the Harvard geneticist David Sinclair, we lose NAD+ as we age, and this decline in sirtuin activity is believed to be a primary reason why our bodies become susceptible to diseases as we grow older. Sinclair’s research suggests that increasing NAD+ levels, including through NMN supplementation, could potentially slow or even reverse certain aging processes.

Unlocking NAD+ Benefits Through Other Means

While NMN is an exciting avenue for enhancing NAD+ levels, it’s not the only one. Polyphenols, plant-based compounds renowned for promoting longevity, exercise, and caloric restriction (reducing calorie intake without malnutrition) can also boost NAD+ levels and activate sirtuins. These methods not only increase cell survival and DNA protection but also offer a plethora of other benefits, such as protecting against diabetes, fatty liver disease, age-related muscle loss (sarcopenia), neurodegeneration, and excess fat accumulation.

NAD+ and Its Role in Metabolism

NAD+ plays a dynamic role in metabolic processes, including glycolysis, the TCA Cycle (also known as the Krebs Cycle or Citric Acid Cycle), and the electron transport chain, all of which occur within our mitochondria and are responsible for producing cellular energy.

As a ligand, NAD+ binds to enzymes and facilitates the transfer of electrons between molecules. Electrons are the atomic currency of cellular energy, and NAD+ effectively serves as the rechargeable battery. When electrons are spent to provide energy, they need a boost to return to their initial state. NAD+ acts as this booster. In cells, NAD+ can either decrease or increase enzyme activity, gene expression, and cell signaling, playing a central role in regulating cellular processes.

NAD+ in DNA Damage Control

With advancing age, organisms accumulate DNA damage due to environmental factors such as radiation, pollution, and imperfect DNA replication. This accumulation of DNA damage is a primary culprit behind the aging process. Fortunately, nearly all cells possess the molecular machinery required to repair this damage, and this machinery relies on NAD+ and energy molecules. Excessive DNA damage can deplete precious cellular resources.

One critical DNA repair protein, PARP (Poly (ADP-ribose) polymerase), depends on NAD+ to function efficiently. Aging individuals often experience decreased NAD+ levels, leading to increased PARP activity and further depletion of NAD+. The accumulation of DNA damage, particularly in mitochondria, exacerbates this depletion.

Why NAD+ Matters to Us

Since its discovery in 1906, NAD+ has been the subject of intensive scientific scrutiny, thanks to its abundance in the body and its indispensable role in vital molecular pathways. Animal studies have demonstrated that increasing NAD+ levels can yield promising results in metabolic regulation, age-related diseases, and even exhibit some anti-aging properties. Conditions like diabetes, cardiovascular diseases, neurodegeneration, and weakened immune systems due to aging could potentially benefit from interventions that target NAD+.

NMN in the Fight Against COVID-19

The COVID-19 pandemic has thrust the world into uncharted territory, with scientists racing to find safe and effective treatments. Gerontologists, experts in the biology of aging, believe that therapies targeting the aging process could offer a unique perspective on combatting the pandemic.

Statistics have revealed that COVID-19 disproportionately affects older adults, with the elderly facing a significantly higher risk of severe outcomes. Some gerontologists propose that tackling “aging” itself could provide a long-term solution to protect older adults from COVID-19 and future infectious diseases. While more research is needed, recent studies have listed NAD+ boosters like NMN and NR as potential treatments. Scientists hypothesize that older adults might benefit from NAD+’s longevity effects, potentially preventing the dangerous overactivation of immune responses known as cytokine storms.

Recent research has shown that NAD+ is crucial for the innate immune defense against viruses. Some scientists are investigating whether NAD+ boosters could help humans combat the pandemic.

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In the midst of this battle, innovative techniques have emerged. Dr. Robert Huizenga of Cedars Sinai Medical Center, faced with severely ill patients, administered an NMN cocktail infused with boosters like zinc as a last resort to calm the cytokine storms triggered by COVID-19. Remarkably, this NMN cocktail led to a rapid reduction in fever and inflammation levels within 12 hours.

NAD+ for a Longer, Healthier Life

NAD+ serves as the fuel that powers sirtuins, guardians of genome integrity and DNA repair. Just as a car can’t run without fuel, sirtuins require NAD+ activation to extend the lifespans of organisms, as shown in animal studies. While promising, the translation of these results.

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Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast

Real NMN is difficult to obtain these days, especially since David Sinclair is working on a new drug that involves NMN. However, we understand the importance of obtaining high-quality NMN, which is why we personally tested and recommend Bucky Labs for your NMN supplementation needs. When it comes to your health and longevity, trust in the best is essential.


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Results of Laboratory Testing for NMN

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